interdisciplinary research

where

ICT meets BIO & NANO

  • Join us!
    Several MSc and PhD student positions are open!
  • New, cost-effective, microfluidic

    MC Testbed

    Low-cost Microfluidic Testbed for Molecular Communications with Integrated Hydrodynamic Gating and Screen-printed Sensors

  • Molecular Communications for

    Workshops at the intersection of molecular communications and synthetic biology towards wetware artificial life.
    (co-organized by CALICO Lab at ALIFE'23 & ALIFE'24

  • Precise molecular signal generation with programmable waveforms in microfluidic communication channels. 

  • New Project [KU Seed]

    Our project on synthesis and functionalization of giant vesicles towards molecular communications with artificial cells awarded the KU Seed Grant

  • Special Feature on

    From molecular cybernetics to network medicine: Interdisciplinary synergies in molecular communications and Internet of Bio-Nano Things. (co-organized by CALICO Lab in IEEE TMBMC)

  • New Project [TUBITAK 1001]

    Our project on adaptive and reconfigurable receiver architectures for molecular communications awarded the TUBITAK 1001 Grant!

  • Molecular Communications getting practical with

    GRAPHENE

    We report on the fabrication of the first micro/nanoscale MC receiver based on graphene field-effect transistor biosensors.

  • New Project [MSCA IF]

    Our project on engineering ligand-receptor interactions for molecular communications has been awarded the MSCA Individual Fellowship!
  • New Project

    Our project on microfluidic molecular communication testbeds with graphene-based receivers has been awarded the TUBITAK 1001 Grant!

[Join us!]
Several MSc and PhD positions are open!  

[Learn more]

[Molecular Communications for Artificial Life]

First workshop at the intersection of molecular communications and synthetic biology towards wetware artificial life.
(co-organized by CALICO Lab at ALIFE’23)

[Visit workshop webpage]

[Special Feature on Bio-Chem-ICTs]
From molecular cybernetics to network medicine: Interdisciplinary synergies in molecular communications and Internet of Bio-Nano Things.
(co-organized by CALICO Lab in IEEE TMBMC)

[Read the editorial]

[Molecular Communications getting practical with GRAPHENE]
We report on the first micro/nanoscale MC receiver based on graphene.
[See recent publications]

[New Project]
Our project ‘REINFORMATION‘ has been awarded the MSCA Individual Fellowship!

[Learn more]

[New Project]
Our project ‘MiMoGraph‘ has been awarded the TUBITAK 1001 grant!

[Learn more]

nano/bio/physical information and communications laboratory

Our current research activities at CALICO Lab revolve around the Internet of Bio-Nano Things (IoBNT), an emerging information and communication technology (ICT) framework aiming at extending our connectivity and control to NANOscale and BIOlogical environments with collaborative networks of artificial micro/nano devices and biological systems.

At the intersection of ICT, nanotechnology and biotechnology, we conduct highly interdisciplinary theoretical and experimental research with the objective of enabling transformative medical, environmental, and industrial applications of IoBNT.

IoBNT is unconventional in every aspect: it involves unconventional things (e.g., engineered bacteria, nanobiosensors, nanoparticles), which communicate through unconventional methods (e.g., molecular communication), operate in unconventional environments (e.g., the human body), and target unconventional applications (e.g., continuous intrabody health monitoring and targeted smart drug delivery without side effects).

In pursuit of practical IoBNT applications, we address several fundamental questions, worded as follows:

  • How to establish reliable communication between highly heterogeneous bio-nano things with severe constraints in size, complexity, and resources
  • How to deal with the adverse conditions of unconventional environments (e.g., time-varying physiological conditions) on bio-nano communications?
  • How to create seamless interfaces between IoBNT systems and conventional macroscale communication networks?
  • How to ensure compatibility and coexistence between artificial IoBNT components and natural biological systems?
  • How to leverage IoBNT to enable novel technologies and applications with significant scientific, economic and societal impact?

To tackle these challenges, our interdisciplinary approach integrates expertise from ICT, microfluidics, biosensors, and nanomaterials. We are currently:

  • Developing realistic molecular communication (MC) models supported by finite-element and particle-based spatial stochastic simulations.
  • Designing practical MC system components utilizing novel nanomaterials (e.g., graphene) and bottom-up synthetic biology techniques.
  • Fabricating microfluidic MC testbeds equipped with micro- and nanoscale MC transceivers.
  • Developing practical, low-complexity modulation, detection, and channel estimation techniques by exploiting nanoscale and biological interactions, such as ligand-receptor dynamics.
  • Investigating new interfaces between nano/macro and bio/cyber systems.

Just as the overarching endeavour of space exploration has given rise to countless spinoff technologies now essential in other fields (e.g., cochlear implants, CMOS image sensors), we anticipate our interdisciplinary efforts in developing practical IoBNT applications will similarly contribute invaluable advancements to ICT-informed understanding of biological systems, drug delivery, biosensors, novel diagnostic and therapeutic approaches, and many others. 

Several MSc and PhD positions are available!